Coupling Supercritical Fluid Chromatography with Internal Standard Corrected Quantitative NMR for Rapid and Accurate Purity Assessment
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Analytical Chemistry
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Wei ZHANG is an associate researcher in the Division of Chemical Metrology and Analytical Science, National Institute of Metrology, P.R. China (NIM). Wei ZHANG was graduated from China pharmaceutical University in 2000, and received bachelor’s degree in pharmaceutical Analysis. Since 2001, he has been engaged in the research of NMR for determination of organic compounds. He worked in NIM focusing on the applications of qNMR (quantitative nuclear magnetic resonance), LC (liquid chromatography) and MS (mass spectrometry) for research of purity and solution certified reference materials (CRMs) He is the first researcher in NIM to use qNMR as one of the main quantitative methods for the development of certified purity reference materials, and has been successfully developed a batch of national primary certified reference materials such as Sudan red and Acrylamide. He extends the scope of accurate value assignment of qNMR from high purity sample to low purity sample by establishing new approaches such as ISRC (internal standard recovery correction)-HPLC-qNMR method. He has participated in 12 international comparisons, organized by CCQM, for purity assessment of organic compounds using qNMR. He has been engaged in the study the performance evaluation methods of nuclear magnetic resonance spectrometer, and completed the first National Calibration Specification for Superconducting Pulsed Fourier Transform Nuclear Magnetic Resonance Spectrometers(JJF1448-2014) as the first author. He was engaged in the research on qNMR applications as a visiting researcher in the Bureau International des Poids et Measures ( BIPM ) in 2016, and 2018, respectively.
China
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